Copper–zinc superoxide dismutase-mediated redox regulation of bortezomib resistance in multiple myeloma

Multiple myeloma (MM) is an incurable B-cell malignancy. The proteasome inhibitor bortezomib (BTZ) is a frontline MM drug; however, intrinsic or acquired resistance to BTZ remains a clinical hurdle. As BTZ induces oxidative stress in MM cells, we queried if altered redox homeostasis promotes BTZ res...

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Dettagli Bibliografici
Pubblicato in:Redox Biol
Autori principali: Salem, Kelley, McCormick, Michael L., Wendlandt, Erik, Zhan, Fenghuang, Goel, Apollina
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2014
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309843/
https://ncbi.nlm.nih.gov/pubmed/25485927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2014.11.002
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