Copper–zinc superoxide dismutase-mediated redox regulation of bortezomib resistance in multiple myeloma

Multiple myeloma (MM) is an incurable B-cell malignancy. The proteasome inhibitor bortezomib (BTZ) is a frontline MM drug; however, intrinsic or acquired resistance to BTZ remains a clinical hurdle. As BTZ induces oxidative stress in MM cells, we queried if altered redox homeostasis promotes BTZ res...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Salem, Kelley, McCormick, Michael L., Wendlandt, Erik, Zhan, Fenghuang, Goel, Apollina
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309843/
https://ncbi.nlm.nih.gov/pubmed/25485927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2014.11.002
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