Regulation of Vascular Tone, Angiogenesis and Cellular Bioenergetics by the 3-Mercaptopyruvate Sulfurtransferase/H(2)S Pathway: Functional Impairment by Hyperglycemia and Restoration by dl-α-Lipoic Acid

Hydrogen sulfide (H(2)S), as a reducing agent and an antioxidant molecule, exerts protective effects against hyperglycemic stress in the vascular endothelium. The mitochondrial enzyme 3-mercaptopyruvate sulfurtransferase (3-MST) is an important biological source of H(2)S. We have recently demonstrat...

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Published in:Mol Med
Main Authors: Coletta, Ciro, Módis, Katalin, Szczesny, Bartosz, Brunyánszki, Attila, Oláh, Gábor, Rios, Ester CS, Yanagi, Kazunori, Ahmad, Akbar, Papapetropoulos, Andreas, Szabo, Csaba
Format: Artigo
Language:Inglês
Published: ScholarOne 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4461574/
https://ncbi.nlm.nih.gov/pubmed/25715337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2015.00035
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