The novel mitochondria-targeted hydrogen sulfide (H(2)S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial cells in vitro

The development of diabetic vascular complications is initiated, at least in part, by mitochondrial reactive oxygen species (ROS) production in endothelial cells. Hyperglycemia induces superoxide production in the mitochondria and initiates changes in the mitochondrial membrane potential that leads...

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Detalhes bibliográficos
Publicado no:Pharmacol Res
Main Authors: Gerő, Domokos, Torregrossa, Roberta, Perry, Alexis, Waters, Alicia, Le-Trionnaire, Sophie, Whatmore, Jacqueline L., Wood, Mark, Whiteman, Matthew
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Invited Perspective
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5113977/
https://ncbi.nlm.nih.gov/pubmed/27565382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2016.08.019
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