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p27T187A knockin identifies Skp2/Cks1 pocket inhibitors for advanced prostate cancer
SCF(Skp2/Cks1) ubiquitinates Thr187-phosphorylated p27 for degradation. Over-expression of Skp2 coupled with under-expression of p27 are frequent characteristics of cancer cells. When the role of SCF(Skp2/Cks1) mediated p27 ubiquitination in cancer was specifically tested by p27 Thr187-to-Ala knocki...
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| Gepubliceerd in: | Oncogene |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5112153/ https://ncbi.nlm.nih.gov/pubmed/27181203 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.175 |
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