Substituting Threonine 187 with Alanine in p27Kip1 Prevents Pituitary Tumorigenesis by Two-Hit Loss of Rb1 and Enhances Humoral Immunity in Old Age

p27Kip1 (p27) is an inhibitor of cyclin-dependent kinases. Inhibiting p27 protein degradation is an actively developing cancer therapy strategy. One focus has been to identify small molecule inhibitors to block recruitment of Thr-187-phosphorylated p27 (p27T187p) to SCF(Skp2/Cks1) ubiquitin ligase....

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Zhao, Hongling, Bauzon, Frederick, Bi, Enguang, Yu, J. Jessica, Fu, Hao, Lu, Zhonglei, Cui, Jinhua, Jeon, Hyungjun, Zang, Xingxing, Ye, B. Hilda, Zhu, Liang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342489/
https://ncbi.nlm.nih.gov/pubmed/25583987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.625350
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