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Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
Bacterial adaptive immunity and genome engineering involving the CRISPR (clustered regularly interspaced short palindromic repeats)–associated (Cas) protein Cas9 begin with RNA-guided DNA unwinding to form an RNA-DNA hybrid and a displaced DNA strand inside the protein. The role of this R-loop struc...
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| 出版年: | Science |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5111852/ https://ncbi.nlm.nih.gov/pubmed/26841432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad8282 |
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