Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage

Bacterial adaptive immunity and genome engineering involving the CRISPR (clustered regularly interspaced short palindromic repeats)–associated (Cas) protein Cas9 begin with RNA-guided DNA unwinding to form an RNA-DNA hybrid and a displaced DNA strand inside the protein. The role of this R-loop struc...

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Bibliografske podrobnosti
izdano v:Science
Main Authors: Jiang, Fuguo, Taylor, David W., Chen, Janice S., Kornfeld, Jack E., Zhou, Kaihong, Thompson, Aubri J., Nogales, Eva, Doudna, Jennifer A.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111852/
https://ncbi.nlm.nih.gov/pubmed/26841432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad8282
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