Inhibition of Both Hsp70 Activity and Tau Aggregation in Vitro Best Predicts Tau Lowering Activity of Small Molecules

Three scaffolds with inhibitory activity against the heat shock protein 70 (Hsp70) family of chaperones have been found to enhance the degradation of the microtubule associated protein tau in cells, neurons, and brain tissue. This is important because tau accumulation is linked to neurodegenerative...

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Veröffentlicht in:ACS Chem Biol
Hauptverfasser: Martin, Mackenzie D., Baker, Jeremy D., Suntharalingam, Amirthaa, Nordhues, Bryce A., Shelton, Lindsey B., Zheng, Dali, Sabbagh, Jonathan J., Haystead, Timothy A.J., Gestwicki, Jason E., Dickey, Chad A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111430/
https://ncbi.nlm.nih.gov/pubmed/27177119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00223
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