Integration of genomics and histology revises diagnosis and enables effective therapy of refractory cancer of unknown primary with PDL1 amplification

Identification of the tissue of origin in cancer of unknown primary (CUP) poses a diagnostic challenge and is critical for directing site-specific therapy. Currently, clinical decision-making in patients with CUP primarily relies on histopathology and clinical features. Comprehensive molecular profi...

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Bibliografiske detaljer
Udgivet i:Cold Spring Harb Mol Case Stud
Main Authors: Gröschel, Stefan, Bommer, Martin, Hutter, Barbara, Budczies, Jan, Bonekamp, David, Heining, Christoph, Horak, Peter, Fröhlich, Martina, Uhrig, Sebastian, Hübschmann, Daniel, Geörg, Christina, Richter, Daniela, Pfarr, Nicole, Pfütze, Katrin, Wolf, Stephan, Schirmacher, Peter, Jäger, Dirk, von Kalle, Christof, Brors, Benedikt, Glimm, Hanno, Weichert, Wilko, Stenzinger, Albrecht, Fröhling, Stefan
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2016
Fag:
Research Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111004/
https://ncbi.nlm.nih.gov/pubmed/27900363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/mcs.a001180
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