Integration of genomics and histology revises diagnosis and enables effective therapy of refractory cancer of unknown primary with PDL1 amplification

Identification of the tissue of origin in cancer of unknown primary (CUP) poses a diagnostic challenge and is critical for directing site-specific therapy. Currently, clinical decision-making in patients with CUP primarily relies on histopathology and clinical features. Comprehensive molecular profi...

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Vydáno v:Cold Spring Harb Mol Case Stud
Hlavní autoři: Gröschel, Stefan, Bommer, Martin, Hutter, Barbara, Budczies, Jan, Bonekamp, David, Heining, Christoph, Horak, Peter, Fröhlich, Martina, Uhrig, Sebastian, Hübschmann, Daniel, Geörg, Christina, Richter, Daniela, Pfarr, Nicole, Pfütze, Katrin, Wolf, Stephan, Schirmacher, Peter, Jäger, Dirk, von Kalle, Christof, Brors, Benedikt, Glimm, Hanno, Weichert, Wilko, Stenzinger, Albrecht, Fröhling, Stefan
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2016
Témata:
Research Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111004/
https://ncbi.nlm.nih.gov/pubmed/27900363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/mcs.a001180
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