Multiple Antibody Lineages in One Donor Target the Glycan-V3 Supersite of the HIV-1 Envelope Glycoprotein and Display a Preference for Quaternary Binding

One of the goals of HIV-1 vaccine development is the elicitation of neutralizing antibodies against vulnerable regions on the envelope glycoprotein (Env) viral spike. Broadly neutralizing antibodies targeting the Env glycan-V3 region (also called the N332 glycan supersite) have been described previo...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Longo, Nancy S., Sutton, Matthew S., Shiakolas, Andrea R., Guenaga, Javier, Jarosinski, Marissa C., Georgiev, Ivelin S., McKee, Krisha, Bailer, Robert T., Louder, Mark K., O'Dell, Sijy, Connors, Mark, Wyatt, Richard T., Mascola, John R., Doria-Rose, Nicole A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5110179/
https://ncbi.nlm.nih.gov/pubmed/27654288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01012-16
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