Multiple Antibody Lineages in One Donor Target the Glycan-V3 Supersite of the HIV-1 Envelope Glycoprotein and Display a Preference for Quaternary Binding

One of the goals of HIV-1 vaccine development is the elicitation of neutralizing antibodies against vulnerable regions on the envelope glycoprotein (Env) viral spike. Broadly neutralizing antibodies targeting the Env glycan-V3 region (also called the N332 glycan supersite) have been described previo...

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Bibliografske podrobnosti
izdano v:J Virol
Main Authors: Longo, Nancy S., Sutton, Matthew S., Shiakolas, Andrea R., Guenaga, Javier, Jarosinski, Marissa C., Georgiev, Ivelin S., McKee, Krisha, Bailer, Robert T., Louder, Mark K., O'Dell, Sijy, Connors, Mark, Wyatt, Richard T., Mascola, John R., Doria-Rose, Nicole A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2016
Teme:
Pathogenesis and Immunity
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5110179/
https://ncbi.nlm.nih.gov/pubmed/27654288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01012-16
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