Multiple Antibody Lineages in One Donor Target the Glycan-V3 Supersite of the HIV-1 Envelope Glycoprotein and Display a Preference for Quaternary Binding

One of the goals of HIV-1 vaccine development is the elicitation of neutralizing antibodies against vulnerable regions on the envelope glycoprotein (Env) viral spike. Broadly neutralizing antibodies targeting the Env glycan-V3 region (also called the N332 glycan supersite) have been described previo...

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Bibliografiset tiedot
Julkaisussa:J Virol
Päätekijät: Longo, Nancy S., Sutton, Matthew S., Shiakolas, Andrea R., Guenaga, Javier, Jarosinski, Marissa C., Georgiev, Ivelin S., McKee, Krisha, Bailer, Robert T., Louder, Mark K., O'Dell, Sijy, Connors, Mark, Wyatt, Richard T., Mascola, John R., Doria-Rose, Nicole A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2016
Aiheet:
Pathogenesis and Immunity
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5110179/
https://ncbi.nlm.nih.gov/pubmed/27654288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01012-16
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