Dexamethasone rapidly suppresses IL-33-stimulated mast cell function by blocking transcription factor activity

Mast cells are critical effectors of allergic disease and can be activated by IL-33, a proinflammatory member of the IL-1 cytokine family. IL-33 worsens the pathology of mast cell–mediated diseases, but therapies to antagonize IL-33 are still forthcoming. Because steroids are the mainstay of allergi...

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Bibliographic Details
Published in:J Leukoc Biol
Main Authors: Paranjape, Anuya, Chernushevich, Oksana, Qayum, Amina Abdul, Spence, Andrew J., Taruselli, Marcela T., Abebayehu, Daniel, Barnstein, Brian O., McLeod, Jamie Josephine Avila, Baker, Bianca, Bajaj, Gurjas S., Chumanevich, Alena P., Oskeritzian, Carole A., Ryan, John J.
Format: Artigo
Language:Inglês
Published: Society for Leukocyte Biology 2016
Subjects:
Inflammation, Extracellular Mediators, & Effector Molecules
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5109997/
https://ncbi.nlm.nih.gov/pubmed/27443878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.3A0316-125R
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