Dexamethasone rapidly suppresses IL-33-stimulated mast cell function by blocking transcription factor activity

Mast cells are critical effectors of allergic disease and can be activated by IL-33, a proinflammatory member of the IL-1 cytokine family. IL-33 worsens the pathology of mast cell–mediated diseases, but therapies to antagonize IL-33 are still forthcoming. Because steroids are the mainstay of allergi...

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Detalhes bibliográficos
Publicado no:J Leukoc Biol
Main Authors: Paranjape, Anuya, Chernushevich, Oksana, Qayum, Amina Abdul, Spence, Andrew J., Taruselli, Marcela T., Abebayehu, Daniel, Barnstein, Brian O., McLeod, Jamie Josephine Avila, Baker, Bianca, Bajaj, Gurjas S., Chumanevich, Alena P., Oskeritzian, Carole A., Ryan, John J.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Leukocyte Biology 2016
Assuntos:
Inflammation, Extracellular Mediators, & Effector Molecules
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5109997/
https://ncbi.nlm.nih.gov/pubmed/27443878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.3A0316-125R
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