Lactic Acid Suppresses IL-33-mediated Mast Cell Inflammatory Responses via Hypoxia Inducible Factor (HIF)-1α-dependent miR-155 Suppression

Lactic acid (LA) is present in tumors, asthma, and wound healing, environments with elevated IL-33 and mast cell infiltration. While IL-33 is a potent mast cell activator, how LA affects IL-33-mediated mast cell function is unknown. To investigate this, mouse bone marrow-derived mast cells (BMMC) we...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:J Immunol
Autori principali: Abebayehu, Daniel, Spence, Andrew J., Qayum, Amina Abdul, Taruselli, Marcela T., McLeod, Jamie J.A., Caslin, Heather L., Chumanevich, Alena P., Kolawole, Elizabeth Motunrayo, Paranjape, Anuya, Baker, Bianca, Ndaw, Victor S., Barnstein, Brian O., Oskeritzian, Carole A., Sell, Scott A., Ryan, John J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026940/
https://ncbi.nlm.nih.gov/pubmed/27559047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600651
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi