Lactic Acid Suppresses IL-33-mediated Mast Cell Inflammatory Responses via Hypoxia Inducible Factor (HIF)-1α-dependent miR-155 Suppression

Lactic acid (LA) is present in tumors, asthma, and wound healing, environments with elevated IL-33 and mast cell infiltration. While IL-33 is a potent mast cell activator, how LA affects IL-33-mediated mast cell function is unknown. To investigate this, mouse bone marrow-derived mast cells (BMMC) we...

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Publicado no:J Immunol
Main Authors: Abebayehu, Daniel, Spence, Andrew J., Qayum, Amina Abdul, Taruselli, Marcela T., McLeod, Jamie J.A., Caslin, Heather L., Chumanevich, Alena P., Kolawole, Elizabeth Motunrayo, Paranjape, Anuya, Baker, Bianca, Ndaw, Victor S., Barnstein, Brian O., Oskeritzian, Carole A., Sell, Scott A., Ryan, John J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026940/
https://ncbi.nlm.nih.gov/pubmed/27559047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600651
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