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Cocrystal transition points: Role of cocrystal solubility, drug solubility, and solubilizing agents

In this manuscript we bring together concepts that are relevant to the solubilization and thermodynamic stability of cocrystals in the presence of drug solubilizing agents. Simple equations are derived that allow calculation of cocrystal solubilization and transition point solubility. Analysis of 10...

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Detalhes bibliográficos
Publicado no:Mol Pharm
Main Authors: Lipert, Maya, Rodríguez-Hornedo, Naír
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5109980/
https://ncbi.nlm.nih.gov/pubmed/26207517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.5b00111
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