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Mechanistic Analysis of Cocrystal Dissolution as a Function of pH and Micellar Solubilization

[Image: see text] The purpose of this work is to provide a mechanistic understanding of the dissolution behavior of cocrystals under the influence of ionization and micellar solubilization. Mass transport models were developed by applying Fick’s law of diffusion to dissolution with simultaneous chem...

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Detalhes bibliográficos
Publicado no:Mol Pharm
Main Authors: Cao, Fengjuan, Amidon, Gordon L., Rodriguez-Hornedo, Nair, Amidon, Gregory E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4783787/
https://ncbi.nlm.nih.gov/pubmed/26877267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.5b00862
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