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Mechanistic Analysis of Cocrystal Dissolution as a Function of pH and Micellar Solubilization

[Image: see text] The purpose of this work is to provide a mechanistic understanding of the dissolution behavior of cocrystals under the influence of ionization and micellar solubilization. Mass transport models were developed by applying Fick’s law of diffusion to dissolution with simultaneous chem...

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Dettagli Bibliografici
Pubblicato in:Mol Pharm
Autori principali: Cao, Fengjuan, Amidon, Gordon L., Rodriguez-Hornedo, Nair, Amidon, Gregory E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2016
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4783787/
https://ncbi.nlm.nih.gov/pubmed/26877267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.5b00862
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