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How cocrystals of weakly basic drugs and acidic coformers might modulate solubility and stability
Cocrystals of a weakly basic drug (nevirapine) with acidic coformers are shown to alter the solubility dependence on pH, and to exhibit a pH(max) above which a less soluble cocrystal becomes more soluble than the drug. The cocrystal solubility advantage can be dialed up or down by solution pH.
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| Publicado en: | Chem Commun (Camb) |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4893792/ https://ncbi.nlm.nih.gov/pubmed/27042997 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6cc00898d |
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