Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS

Evidence of misfolded wild-type superoxide dismutase 1 (SOD1) has been detected in spinal cords of sporadic ALS (sALS) patients, suggesting an etiological relationship to SOD1-associated familial ALS (fALS). Given that there are currently a number of promising therapies under development that target...

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Detaylı Bibliyografya
Yayımlandı:Acta Neuropathol
Asıl Yazarlar: Ayers, Jacob I., Diamond, Jeffrey, Sari, Adriana, Fromholt, Susan, Galaleldeen, Ahmad, Ostrow, Lyle W., Glass, Jonathan D., Hart, P. John, Borchelt, David R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5107152/
https://ncbi.nlm.nih.gov/pubmed/27704280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-016-1623-4
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