Misfolded SOD1 is not a primary component of sporadic ALS

A common feature of inherited and sporadic ALS is accumulation of abnormal proteinaceous inclusions in motor neurons and glia. SOD1 is the major protein component accumulating in patients with SOD1 mutations, as well as in mutant SOD1 mouse models. ALS-linked mutations of SOD1 have been shown to inc...

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Detaylı Bibliyografya
Yayımlandı:Acta Neuropathol
Asıl Yazarlar: Da Cruz, Sandrine, Bui, Anh, Saberi, Shahram, Lee, Sandra K., Stauffer, Jennifer, McAlonis-Downes, Melissa, Schulte, Derek, Pizzo, Donald P., Parone, Philippe A., Cleveland, Don W., Ravits, John
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5472502/
https://ncbi.nlm.nih.gov/pubmed/28247063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-017-1688-8
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