Misfolded SOD1 is not a primary component of sporadic ALS

A common feature of inherited and sporadic ALS is accumulation of abnormal proteinaceous inclusions in motor neurons and glia. SOD1 is the major protein component accumulating in patients with SOD1 mutations, as well as in mutant SOD1 mouse models. ALS-linked mutations of SOD1 have been shown to inc...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Da Cruz, Sandrine, Bui, Anh, Saberi, Shahram, Lee, Sandra K., Stauffer, Jennifer, McAlonis-Downes, Melissa, Schulte, Derek, Pizzo, Donald P., Parone, Philippe A., Cleveland, Don W., Ravits, John
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5472502/
https://ncbi.nlm.nih.gov/pubmed/28247063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-017-1688-8
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