Misfolded SOD1 Associated with Motor Neuron Mitochondria Alters Mitochondrial Shape and Distribution Prior to Clinical Onset

Mutations in superoxide dismutase (SOD1) are causative for inherited amyotrophic lateral sclerosis. A proportion of SOD1 mutant protein is misfolded onto the cytoplasmic face of mitochondria in one or more spinal cord cell types. By construction of mice in which mitochondrially targeted enhanced gre...

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Detalhes bibliográficos
Main Authors: Vande Velde, Christine, McDonald, Karli K., Boukhedimi, Yasmin, McAlonis-Downes, Melissa, Lobsiger, Christian S., Bel Hadj, Samar, Zandona, Andre, Julien, Jean-Pierre, Shah, Sameer B., Cleveland, Don W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136936/
https://ncbi.nlm.nih.gov/pubmed/21779368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022031
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