Tumor-Induced IL-6 Reprograms Host Metabolism to Suppress Anti-tumor Immunity

In patients with cancer, the wasting syndrome, cachexia, is associated with caloric deficiency. Here, we describe tumor-induced alterations of the host metabolic response to caloric deficiency that cause intratumoral immune suppression. In pre-cachectic mice with transplanted colorectal cancer or au...

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Gepubliceerd in:Cell Metab
Hoofdauteurs: Flint, Thomas R., Janowitz, Tobias, Connell, Claire M., Roberts, Edward W., Denton, Alice E., Coll, Anthony P., Jodrell, Duncan I., Fearon, Douglas T.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cell Press 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5106372/
https://ncbi.nlm.nih.gov/pubmed/27829137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2016.10.010
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