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AMD3100/Plerixafor overcomes immune inhibition by the CXCL12–KRT19 coating on pancreatic and colorectal cancer cells

A recent Phase 1 clinical study of the immunological effects of inhibiting the chemokine receptor, CXCR4, in patients with pancreatic ductal adenocarcinoma or colorectal cancer suggests that stimulation of CXCR4 on immune cells suppresses the intratumoural immune reaction. Here, we discuss how CXCR4...

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Podrobná bibliografie
Vydáno v:Br J Cancer
Hlavní autoři: Fearon, Douglas T., Janowitz, Tobias
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8292464/
https://ncbi.nlm.nih.gov/pubmed/33772153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-021-01315-y
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