Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti–PD-L1 immunotherapy in pancreatic cancer

An autochthonous model of pancreatic ductal adenocarcinoma (PDA) permitted the analysis of why immunotherapy is ineffective in this human disease. Despite finding that PDA-bearing mice had cancer cell-specific CD8(+) T cells, the mice, like human patients with PDA, did not respond to two immunologic...

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Detalhes bibliográficos
Main Authors: Feig, Christine, Jones, James O., Kraman, Matthew, Wells, Richard J. B., Deonarine, Andrew, Chan, Derek S., Connell, Claire M., Roberts, Edward W., Zhao, Qi, Caballero, Otavia L., Teichmann, Sarah A., Janowitz, Tobias, Jodrell, Duncan I., Tuveson, David A., Fearon, Douglas T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3864274/
https://ncbi.nlm.nih.gov/pubmed/24277834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320318110
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