Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti–PD-L1 immunotherapy in pancreatic cancer

An autochthonous model of pancreatic ductal adenocarcinoma (PDA) permitted the analysis of why immunotherapy is ineffective in this human disease. Despite finding that PDA-bearing mice had cancer cell-specific CD8(+) T cells, the mice, like human patients with PDA, did not respond to two immunologic...

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Bibliographic Details
Main Authors: Feig, Christine, Jones, James O., Kraman, Matthew, Wells, Richard J. B., Deonarine, Andrew, Chan, Derek S., Connell, Claire M., Roberts, Edward W., Zhao, Qi, Caballero, Otavia L., Teichmann, Sarah A., Janowitz, Tobias, Jodrell, Duncan I., Tuveson, David A., Fearon, Douglas T.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3864274/
https://ncbi.nlm.nih.gov/pubmed/24277834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320318110
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