Acyclic nucleoside phosphonates containing the amide bond

ABSTRACT: To study the influence of a linker rigidity and donor–acceptor properties, the P–CH(2)–O–CHR– fragment in acyclic nucleoside phosphonates (e.g., acyclovir, tenofovir) was replaced by the P–CH(2)–HN–C(O)– residue. The respective phosphonates were synthesized in good yields by coupling the s...

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Bibliografiske detaljer
Udgivet i:Monatsh Chem
Main Authors: Głowacka, Iwona E., Piotrowska, Dorota G., Andrei, Graciela, Schols, Dominique, Snoeck, Robert, Wróblewski, Andrzej E.
Format: Artigo
Sprog:Inglês
Udgivet: Springer Vienna 2016
Fag:
Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5101293/
https://ncbi.nlm.nih.gov/pubmed/27881885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00706-016-1848-x
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