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Acyclic nucleoside phosphonates containing the amide bond
ABSTRACT: To study the influence of a linker rigidity and donor–acceptor properties, the P–CH(2)–O–CHR– fragment in acyclic nucleoside phosphonates (e.g., acyclovir, tenofovir) was replaced by the P–CH(2)–HN–C(O)– residue. The respective phosphonates were synthesized in good yields by coupling the s...
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| Publicado en: | Monatsh Chem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Springer Vienna
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5101293/ https://ncbi.nlm.nih.gov/pubmed/27881885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00706-016-1848-x |
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