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Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca(2+) release
BACKGROUND: Junctophilin-2 (JPH2) is the primary structural protein for coupling of transverse (T)-tubule associated cardiac L-type Ca channels and type-2 ryanodine receptors on the sarcoplasmic reticulum within junctional membrane complexes in cardiomyocytes. Effective signaling between these chann...
Tallennettuna:
| Julkaisussa: | Int J Cardiol |
|---|---|
| Päätekijät: | , , , , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2016
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5101129/ https://ncbi.nlm.nih.gov/pubmed/27760414 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijcard.2016.10.021 |
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