Mutation E169K in junctophilin-2 causes atrial fibrillation due to impaired RyR2 stabilization

OBJECTIVES: To study the role of junctophilin 2 (JPH2) in atrial fibrillation (AF). BACKGROUND: JPH2 is believed to have an important role in sarcoplasmic reticulum (SR) Ca(2+) handling and modulation of ryanodine receptor Ca(2+) channels (RyR2). Whereas defective RyR2-mediated Ca(2+) release contri...

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Hoofdauteurs: Beavers, David L., Wang, Wei, Ather, Sameer, Voigt, Niels, Garbino, Alejandro, Dixit, Sayali S., Landstrom, Andrew P., Li, Na, Wang, Qiongling, Olivotto, Iacopo, Dobrev, Dobromir, Ackerman, Michael J., Wehrens, Xander H.T.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3830688/
https://ncbi.nlm.nih.gov/pubmed/23973696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2013.06.052
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