Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca(2+) release

BACKGROUND: Junctophilin-2 (JPH2) is the primary structural protein for coupling of transverse (T)-tubule associated cardiac L-type Ca channels and type-2 ryanodine receptors on the sarcoplasmic reticulum within junctional membrane complexes in cardiomyocytes. Effective signaling between these chann...

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Udgivet i:Int J Cardiol
Main Authors: Reynolds, Julia O., Quick, Ann P., Wang, Qiongling, Beavers, David L., Philippen, Leonne E., Showell, Jordan, Barreto-Torres, Giselle, Theurauf, Donna J., Doroudgar, Shirin, Glembotski, Christopher C., Wehrens, Xander H.T.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5101129/
https://ncbi.nlm.nih.gov/pubmed/27760414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijcard.2016.10.021
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