Development of an Orally Available and Central Nervous System (CNS)-Penetrant Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-à-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis

New therapies are needed for the treatment of toxoplasmosis, which is a disease caused by the protozoan parasite Toxoplasma gondii. To this end, we previously developed a potent and selective inhibitor (compound 1) of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) that possesses anti...

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Veröffentlicht in:J Med Chem
Hauptverfasser: Vidadala, Rama Subba Rao, Rivas, Kasey L., Ojo, Kayode K., Hulverson, Matthew A., Zambriski, Jennifer A., Bruzual, Igor, Schultz, Tracey L., Huang, Wenlin, Zhang, Zhongsheng, Scheele, Suzanne, DeRocher, Amy E., Choi, Ryan, Barrett, Lynn K., Siddaramaiah, Latha Kallur, Hol, Wim G. J., Fan, Erkang, Merritt, Ethan A., Parsons, Marilyn, Freiberg, Gail, Marsh, Kennan, Kempf, Dale, Carruthers, Vern B., Isoherranen, Nina, Doggett, J. Stone, Van Voorhis, Wesley C., Maly, Dustin J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5100899/
https://ncbi.nlm.nih.gov/pubmed/27309760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00760
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