Development of an Orally Available and Central Nervous System (CNS)-Penetrant Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-à-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis

New therapies are needed for the treatment of toxoplasmosis, which is a disease caused by the protozoan parasite Toxoplasma gondii. To this end, we previously developed a potent and selective inhibitor (compound 1) of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) that possesses anti...

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書誌詳細
出版年:J Med Chem
主要な著者: Vidadala, Rama Subba Rao, Rivas, Kasey L., Ojo, Kayode K., Hulverson, Matthew A., Zambriski, Jennifer A., Bruzual, Igor, Schultz, Tracey L., Huang, Wenlin, Zhang, Zhongsheng, Scheele, Suzanne, DeRocher, Amy E., Choi, Ryan, Barrett, Lynn K., Siddaramaiah, Latha Kallur, Hol, Wim G. J., Fan, Erkang, Merritt, Ethan A., Parsons, Marilyn, Freiberg, Gail, Marsh, Kennan, Kempf, Dale, Carruthers, Vern B., Isoherranen, Nina, Doggett, J. Stone, Van Voorhis, Wesley C., Maly, Dustin J.
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5100899/
https://ncbi.nlm.nih.gov/pubmed/27309760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00760
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