Charge-mediated Fab-Fc interactions in an IgG1 antibody induce reversible self-association, cluster formation, and elevated viscosity

Concentration-dependent reversible self-association (RSA) of monoclonal antibodies (mAbs) poses a challenge to their pharmaceutical development as viable candidates for subcutaneous delivery. While the role of the antigen-binding fragment (Fab) in initiating RSA is well-established, little evidence...

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Udgivet i:MAbs
Main Authors: Arora, Jayant, Hu, Yue, Esfandiary, Reza, Sathish, Hasige A., Bishop, Steven M., Joshi, Sangeeta B., Middaugh, C. Russell, Volkin, David B., Weis, David D.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2016
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098451/
https://ncbi.nlm.nih.gov/pubmed/27560842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1222342
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