Tumour CD274 (PD-L1) expression and T cells in colorectal cancer

OBJECTIVE: Evidence suggests that CD274 (PD-L1, B7-H1) immune checkpoint ligand repress anti-tumour immunity through its interaction with the PDCD1 (programmed cell death 1, PD-1) receptor of T lymphocytes in various tumours. We hypothesised that tumour CD274 expression levels might be inversely ass...

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Detalhes bibliográficos
Publicado no:Gut
Main Authors: Masugi, Yohei, Nishihara, Reiko, Yang, Juhong, Mima, Kosuke, da Silva, Annacarolina, Shi, Yan, Inamura, Kentaro, Cao, Yin, Song, Mingyang, Nowak, Jonathan A., Liao, Xiaoyun, Nosho, Katsuhiko, Chan, Andrew T., Giannakis, Marios, Bass, Adam J., Hodi, F. Stephen, Freeman, Gordon J., Rodig, Scott, Fuchs, Charles S., Qian, Zhi Rong, Ogino, Shuji
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5097696/
https://ncbi.nlm.nih.gov/pubmed/27196573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2016-311421
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