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Catalytic, Diastereoselective 1,2-Difluorination of Alkenes

We describe a direct, catalytic approach to the 1,2-difluorination of alkenes. The method utilizes a nucleophilic fluoride source and an oxidant in conjunction with an aryl iodide catalyst and is applicable to alkenes with all types of substitution patterns. In general, the vicinal difluoride produc...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Banik, Steven M., Medley, Jonathan William, Jacobsen, Eric N.
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5097459/
https://ncbi.nlm.nih.gov/pubmed/27046019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b02391
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