Red‐shifted channelrhodopsin stimulation restores light responses in blind mice, macaque retina, and human retina

Targeting the photosensitive ion channel channelrhodopsin‐2 (ChR2) to the retinal circuitry downstream of photoreceptors holds promise in treating vision loss caused by retinal degeneration. However, the high intensity of blue light necessary to activate channelrhodopsin‐2 exceeds the safety thresho...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:EMBO Mol Med
Prif Awduron: Sengupta, Abhishek, Chaffiol, Antoine, Macé, Emilie, Caplette, Romain, Desrosiers, Mélissa, Lampič, Maruša, Forster, Valérie, Marre, Olivier, Lin, John Y, Sahel, José‐Alain, Picaud, Serge, Dalkara, Deniz, Duebel, Jens
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2016
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5090658/
https://ncbi.nlm.nih.gov/pubmed/27679671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201505699
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