Red‐shifted channelrhodopsin stimulation restores light responses in blind mice, macaque retina, and human retina

Targeting the photosensitive ion channel channelrhodopsin‐2 (ChR2) to the retinal circuitry downstream of photoreceptors holds promise in treating vision loss caused by retinal degeneration. However, the high intensity of blue light necessary to activate channelrhodopsin‐2 exceeds the safety thresho...

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Detalles Bibliográficos
Publicado en:EMBO Mol Med
Main Authors: Sengupta, Abhishek, Chaffiol, Antoine, Macé, Emilie, Caplette, Romain, Desrosiers, Mélissa, Lampič, Maruša, Forster, Valérie, Marre, Olivier, Lin, John Y, Sahel, José‐Alain, Picaud, Serge, Dalkara, Deniz, Duebel, Jens
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2016
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5090658/
https://ncbi.nlm.nih.gov/pubmed/27679671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201505699
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