Targeting Channelrhodopsin-2 to ON-bipolar Cells With Vitreally Administered AAV Restores ON and OFF Visual Responses in Blind Mice

Most inherited retinal dystrophies display progressive photoreceptor cell degeneration leading to severe visual impairment. Optogenetic reactivation of retinal neurons mediated by adeno-associated virus (AAV) gene therapy has the potential to restore vision regardless of patient-specific mutations....

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Macé, Emilie, Caplette, Romain, Marre, Olivier, Sengupta, Abhishek, Chaffiol, Antoine, Barbe, Peggy, Desrosiers, Mélissa, Bamberg, Ernst, Sahel, Jose-Alain, Picaud, Serge, Duebel, Jens, Dalkara, Deniz
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270733/
https://ncbi.nlm.nih.gov/pubmed/25095892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.154
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