Targeting Channelrhodopsin-2 to ON-bipolar Cells With Vitreally Administered AAV Restores ON and OFF Visual Responses in Blind Mice

Most inherited retinal dystrophies display progressive photoreceptor cell degeneration leading to severe visual impairment. Optogenetic reactivation of retinal neurons mediated by adeno-associated virus (AAV) gene therapy has the potential to restore vision regardless of patient-specific mutations....

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Dettagli Bibliografici
Pubblicato in:Mol Ther
Autori principali: Macé, Emilie, Caplette, Romain, Marre, Olivier, Sengupta, Abhishek, Chaffiol, Antoine, Barbe, Peggy, Desrosiers, Mélissa, Bamberg, Ernst, Sahel, Jose-Alain, Picaud, Serge, Duebel, Jens, Dalkara, Deniz
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270733/
https://ncbi.nlm.nih.gov/pubmed/25095892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.154
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