Targeting Channelrhodopsin-2 to ON-bipolar Cells With Vitreally Administered AAV Restores ON and OFF Visual Responses in Blind Mice

Most inherited retinal dystrophies display progressive photoreceptor cell degeneration leading to severe visual impairment. Optogenetic reactivation of retinal neurons mediated by adeno-associated virus (AAV) gene therapy has the potential to restore vision regardless of patient-specific mutations....

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Detalles Bibliográficos
Publicado en:Mol Ther
Main Authors: Macé, Emilie, Caplette, Romain, Marre, Olivier, Sengupta, Abhishek, Chaffiol, Antoine, Barbe, Peggy, Desrosiers, Mélissa, Bamberg, Ernst, Sahel, Jose-Alain, Picaud, Serge, Duebel, Jens, Dalkara, Deniz
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2015
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270733/
https://ncbi.nlm.nih.gov/pubmed/25095892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.154
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