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mTOR inhibition with rapamycin mitigates radiation-induced pulmonary fibrosis in a murine model
BACKGROUND: Radiation-induced pulmonary fibrosis (RIPF) is a late toxicity of therapeutic radiation. mTOR signaling drives several processes implicated in RIPF, including inflammatory cytokine production, fibroblast proliferation, and epithelial senescence. We sought to determine if mTOR inhibition...
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| Publicado no: | Int J Radiat Oncol Biol Phys |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5089209/ https://ncbi.nlm.nih.gov/pubmed/27663762 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2016.07.026 |
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