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A truncated Plasminogen Activator Inhibitor-1 protein protects from pulmonary fibrosis mediated by irradiation in a murine model
PURPOSE/OBJECTIVES: Fibrosis is a late toxicity of thoracic irradiation that can result in substantial morbidity. Plasminogen activator inhibitor-1 (PAI-1) is a critical mediator of cellular senescence and fibrin stabilization. We sought to determine if the delivery of recombinant truncated PAI-1 pr...
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| Publicado no: | Int J Radiat Oncol Biol Phys |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4838903/ https://ncbi.nlm.nih.gov/pubmed/26883561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2015.11.044 |
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