A truncated Plasminogen Activator Inhibitor-1 protein protects from pulmonary fibrosis mediated by irradiation in a murine model

PURPOSE/OBJECTIVES: Fibrosis is a late toxicity of thoracic irradiation that can result in substantial morbidity. Plasminogen activator inhibitor-1 (PAI-1) is a critical mediator of cellular senescence and fibrin stabilization. We sought to determine if the delivery of recombinant truncated PAI-1 pr...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Int J Radiat Oncol Biol Phys
Hlavní autoři: Chung, Eun Joo, McKay-Corkum, Grace, Chung, Su, White, Ayla, Scroggins, Bradley T., Mitchell, James B., Mulligan-Kehoe, Mary Jo, Citrin, Deborah
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838903/
https://ncbi.nlm.nih.gov/pubmed/26883561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2015.11.044
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky