Mithramycin A enhances tumor sensitivity to mitotic catastrophe resulting from DNA damage

BACKGROUND: Specificity protein 1 (Sp1) is involved in the transcription of several genes implicated in tumor maintenance. We investigated the effects of Mithramycin A (MTA), an inhibitor of SP1 DNA binding, on radiation response. METHODS: Clonogenic survival after irradiation was assessed in tumor...

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Detalhes bibliográficos
Publicado no:Int J Radiat Oncol Biol Phys
Main Authors: Scroggins, Bradley T., Burkeen, Jeffrey, White, Ayla O., Chung, Eun Joo, Wei, Darmood, Chung, Su I., Valle, Luca F., Patil, Shilpa S., McKay-Corkum, Grace, Hudak, Kathryn E., Linehan, W. Marston, Citrin, Deborah E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777897/
https://ncbi.nlm.nih.gov/pubmed/29157749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2017.09.049
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