mTOR inhibition with rapamycin mitigates radiation-induced pulmonary fibrosis in a murine model

BACKGROUND: Radiation-induced pulmonary fibrosis (RIPF) is a late toxicity of therapeutic radiation. mTOR signaling drives several processes implicated in RIPF, including inflammatory cytokine production, fibroblast proliferation, and epithelial senescence. We sought to determine if mTOR inhibition...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Int J Radiat Oncol Biol Phys
Egile Nagusiak: Chung, Eun Joo, Sowers, Anastasia, Thetford, Angela, McKay-Corkum, Grace, Chung, Su I., Mitchell, James B., Citrin, Deborah E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5089209/
https://ncbi.nlm.nih.gov/pubmed/27663762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2016.07.026
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