Gα12 is required for renal cystogenesis induced by Pkd1 inactivation

Mutation of PKD1, encoding the protein polycystin-1 (PC1), is the main cause of autosomal dominant polycystic kidney disease (ADPKD). The signaling pathways downstream of PC1 in ADPKD are still not fully understood. Here, we provide genetic evidence for the necessity of Gα12 (encoded by Gna12, herea...

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Veröffentlicht in:J Cell Sci
Hauptverfasser: Wu, Yong, Xu, Jen X., El-Jouni, Wassim, Lu, Tzongshi, Li, Suyan, Wang, Qingyi, Tran, Mei, Yu, Wanfeng, Wu, Maoqing, Barrera, Ivan E., Bonventre, Joseph V., Zhou, Jing, Denker, Bradley M., Kong, Tianqing
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists Ltd 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087651/
https://ncbi.nlm.nih.gov/pubmed/27505895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.190496
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