Gα12 is required for renal cystogenesis induced by Pkd1 inactivation

Mutation of PKD1, encoding the protein polycystin-1 (PC1), is the main cause of autosomal dominant polycystic kidney disease (ADPKD). The signaling pathways downstream of PC1 in ADPKD are still not fully understood. Here, we provide genetic evidence for the necessity of Gα12 (encoded by Gna12, herea...

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Dettagli Bibliografici
Pubblicato in:J Cell Sci
Autori principali: Wu, Yong, Xu, Jen X., El-Jouni, Wassim, Lu, Tzongshi, Li, Suyan, Wang, Qingyi, Tran, Mei, Yu, Wanfeng, Wu, Maoqing, Barrera, Ivan E., Bonventre, Joseph V., Zhou, Jing, Denker, Bradley M., Kong, Tianqing
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists Ltd 2016
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087651/
https://ncbi.nlm.nih.gov/pubmed/27505895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.190496
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