Gα12 is required for renal cystogenesis induced by Pkd1 inactivation

Mutation of PKD1, encoding the protein polycystin-1 (PC1), is the main cause of autosomal dominant polycystic kidney disease (ADPKD). The signaling pathways downstream of PC1 in ADPKD are still not fully understood. Here, we provide genetic evidence for the necessity of Gα12 (encoded by Gna12, herea...

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Detaylı Bibliyografya
Yayımlandı:J Cell Sci
Asıl Yazarlar: Wu, Yong, Xu, Jen X., El-Jouni, Wassim, Lu, Tzongshi, Li, Suyan, Wang, Qingyi, Tran, Mei, Yu, Wanfeng, Wu, Maoqing, Barrera, Ivan E., Bonventre, Joseph V., Zhou, Jing, Denker, Bradley M., Kong, Tianqing
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Company of Biologists Ltd 2016
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087651/
https://ncbi.nlm.nih.gov/pubmed/27505895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.190496
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