Gα12 is required for renal cystogenesis induced by Pkd1 inactivation

Mutation of PKD1, encoding the protein polycystin-1 (PC1), is the main cause of autosomal dominant polycystic kidney disease (ADPKD). The signaling pathways downstream of PC1 in ADPKD are still not fully understood. Here, we provide genetic evidence for the necessity of Gα12 (encoded by Gna12, herea...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Wu, Yong, Xu, Jen X., El-Jouni, Wassim, Lu, Tzongshi, Li, Suyan, Wang, Qingyi, Tran, Mei, Yu, Wanfeng, Wu, Maoqing, Barrera, Ivan E., Bonventre, Joseph V., Zhou, Jing, Denker, Bradley M., Kong, Tianqing
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087651/
https://ncbi.nlm.nih.gov/pubmed/27505895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.190496
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