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H(2)O(2) activates G protein, α 12 to disrupt the junctional complex and enhance ischemia reperfusion injury
The epithelial cell tight junction separates apical and basolateral domains and is essential for barrier function. Disruption of the tight junction is a hallmark of epithelial cell damage and can lead to end organ damage including renal failure. Herein, we identify Gα12 activation by H(2)O(2) leadin...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3340086/ https://ncbi.nlm.nih.gov/pubmed/22493269 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1116800109 |
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